The present study was performed to evaluate the antihyperglycemic effects of yesaka, an ayurvedic polyherbal formulation and metformin in high fat diet-streptozotocin induced diabetic rats. Diabetes was induced by feeding Sprague Dawley rats with high-fat diet (HFD) for two months followed by a single dose of streptozotocin (STZ, 30 mg/kg intraperitoneally). All the diabetic rats were orally treated with metformin as standard (300 mg/kg), yesaka (1.8 ml/kg and 3.6 ml/kg) and with combination of formulation and standard for 4 weeks. The results were evaluated by significant restoration of body weight, decreased levels of plasma glucose, total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) while increased high density lipoprotein cholesterol (HDL-C) levels in all the treatment groups compared to diabetic. These results demonstrated the prominent antidiabetic effect of yesaka in HFD-fed STZ-treated diabetic rats along with metformin. Hence, may be a promising candidate in the treatment and management of diabetes.
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